2 edition of Aerosol deposition and airway-to-perfusate transfer in the isolated, perfused rat lung. found in the catalog.
Aerosol deposition and airway-to-perfusate transfer in the isolated, perfused rat lung.
Nesta Sia n Rowlands Roberts
Thesis (PhD) - University of Aston in Birmingham, 1984.
The three physical mechanisms usually considered for aerosol particle deposition in the human lung include the following. Inertial impaction Gravitational settling (sedimentation) Diffusion (Brownian motion) The purpose of the end-inspiratory breath hold used in aerosol delivery is that it allows better what? For example, controlled drug aerosol release and targeting to specific regions of the lung is a novel way to combat lung diseases, diabetes, virus infections, cancers, etc. Determination of feasible air-particle streams is a prerequisite for the development of such delivery devices, say, smart inhalers.
That is, the lung volume at which an aerosol bolus is introduced into the airstream (another variable of the manner of inhalation) affects the site of deposition. An aerosol bolus at the end of. deposition at the intended site of action in the lung. Op-timizing drug delivery to the lung requires consideration of a multitude of factors that influence aerosol delivery in the mechanically ventilated patient. 3,10 To determine lung deposition in mechanically venti-lated patients investigators employed gamma scintigraphy.
Aerosol delivery to the lungs of intubated patients is usually less than 10% when using a conventional nebulizer in the ventilator circuit (Crit Care Med 81, ). We have recently developed a 1 mm coaxial (OD) design catheter (Trudell Medical, London, Canada) which can be placed directly in the airways and produce an aerosol at its tip. Since the upper airway (and. Inspiratory flow in a multigeneration pig lung airways was numerically studied at a steady inlet flow rate of × 10 −4 m 3 /s corresponding to a Reynolds number of in the trachea. The model was validated by comparing velocity distributions with previous measurements and simulations in .
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The isolated, perfused rat lung preparation was modified to allow characterized solid aerosol delivery. Deposition and airway-to-perfusate transfer of disodium fluorescein from micron dae solid aerosols were studied under different ventilatory regimes.
The lungs inhaled from an aerosol stream of constant concentration via a tracheal by: The isolated, perfused rat lung preparation was modified to allow characterized solid aerosol delivery. Deposition and airway-to-perfusate transfer of disodium fluorescein from 3–4 μm d ae solid aerosols were studied under different ventilatory regimes.
The lungs inhaled from an aerosol stream of constant concentration via a tracheal by: Aerosol deposition and airway-to-perfusate transfer in the isolated, perfused rat lung Author: Roberts, Nesta S. ISNI: X Awarding Body: University of Aston in Birmingham Current Institution: Aston University Date of Aerosol deposition and airway-to-perfusate transfer in the isolated.
Using the recently developed DustGun aerosol technology, we exposed by inhalation for approximately 1 min the isolated and perfused rat lung (IPL) to respirable dry particle aerosols of the three. The isolated, perfused rat lung preparation was modified to allow characterized solid aerosol delivery.
Deposition and airway-to-perfusate transfer of disodium fluorescein from micron dae. The isolated perfused lung preparation has been used in rats, guinea pigs, rabbits, dogs, and monkeys (Sakagami M., ).
The preparation, as shown in Figure 5A–B, consists of peristaltic pumps and a tubing assembly to carry the perfusate to and from the lung, and a double-jacketed artificial thorax to house the isolated perfused lung at The pharmacokinetics of several lung disposition pathways for pulmonary insulin were studied and modeled in the isolated perfused rat lung (IPRL).
Insulin solution was administered by forced instillation into the airways of the IPRL as or ml doses of coarse spray, with or without bacitracin (BAC), N -ethylmaleimide (NEM) and atrial.
1. Introduction. The alveolar surface of the lungs represents a very large and thin barrier separating inhaled gases and particles from the blood (Weibel et al., ).Knowledge of aerosol deposition in the alveolar region is important for the toxicological assessment of inhaled pollutants ().Similarly, the alveolar region is the target for the deposition and absorption of systemically acting.
The isolated perfused lung model is often used to establish the mechanisms of drug absorption and deposition in the lungs.
The shortcoming of ex vivo methods include relatively shortened timeframes for data collections due to the viability of the perfused lungs, complex experimental set up, and the absence of tracheo-bronchial circulation and.
Purpose. To study the release and absorption of peptidoleukotrienes (PLTs) from the airways of the guinea pig lung following calcium ionophore A (CI), benzalkonium chloride (BAC), ethylene diamine tetra-acetic acid (EDTA) or ovalbumin (OA) challenge. Methods. PLT C4/D4/E4 were quantified in the perfusate of the isolated perfused guinea pig lung (IPGPL) following intratracheal.
Particle behavior in the human respiratory tract is well understood and can be used to (1) estimate particle deposition in all regions of the respiratory tract for any aerosol respired at any pattern, and (2) optimize targeting of all regions of the respiratory tract in respiratory drug horacic and alveolar regions can effectively be targeted with mono- and polydisperse aerosols.
Peter R. Byron's research works with 3, citations and 7, reads, including: In Vitro Tests for Aerosol Deposition. VI: Realistic Testing with Different Mouth–Throat Models and In Vitro.
In an isolated perfused rat lung (IPRL) model, the same group reported that co‐administration into the airways of a P‐gp inhibitor had no effect upon the pulmonary absorption profile of digoxin. 16 These limited studies would suggest that P‐gp may have little influence in limiting the airway absorption of P‐gp substrates into the blood.
Koblinger L., Hofmann W. Monte Carlo modeling of aerosol deposition in human lungs. Part I: Simulation of particle transport in a stochastic lung structure. Aerosol Sci.
; – doi: /(90)D. [Google Scholar]. Purpose: To evaluate the ability of human airway epithelial cell layers and a simple rat isolated perfused lung (IPL) model to predict pulmonary drug absorption in rats in vivo. Solute absorption from the airways was compared and modeled in vivo and in vitro isolated perfused rat lung (IPRL), and its regional kinetic descriptors in the presence of competing mucociliary escalator were estimated.
kDa fluorophore‐labeled polyhydroxyethylaspartamide (F‐PHEA), FITC‐labeled dextran 40 (FD‐4) and sodium fluorescein (F‐Na) were used as model solutes. Successful aerosol therapy generally depends on the small percentage (typically 10 percent) of the drug dose delivered to the lungs from metered-dose inhalers (MDIs), nebulizers, and dry powder inhalers.
Deposition of therapeutic aerosols occurs by inertial impaction (in the oropharynx and large conducting airways) and by gravitational sedimentation (in the small conducting airways and alveoli.
For the analysis, isolated perfused rat lung homogenate (50 µL), lung perfusate (50 µL), and microsomal suspension (50 µL) were protein precipitated by the addition of acetonitrile ( µL) containing formic acid (%, v/v), and an analytical internal standard.
Final aerosol sizes exiting the TB region and entering the alveolar airways were all greater than 3 μm, which is sufficient to ensure full lung deposition of the aerosol. Increasing flow rate from SD to QD inhalation was observed to decrease TB deposition fractions by a factor of 2×, which represents the opposite trend of current fixed.
count, it seems that for aerosol therapy we require as ideals: (1) aerosol MMAD deposition, (2)slow,steadyinhalation, and(3)a period of breath-holding on completion of inhalation. These ideals are hard to achieve for metered-dose. In an isolated perfused rat lung (IPRL) model, the same group reported that co-administration into the airways of a P-gp inhibitor had no effect upon the pulmonary absorption profile of digoxin.
16 These limited studies would suggest that P-gp may have little influence in limiting the airway absorption of P-gp substrates into the blood.Asymmetrical Aerosol Deposition in an Idealized Mouth With a DPI Mouthpiece Inlet,” An Isolated Perfused Rat Lung Preparation for the Study of Aerosolized Drug Deposition and Absorption,” Suitability of the Upper Airway Models Obtained from MRI Studies in Simulating Drug Lung Deposition from Inhalers,” Pharm.
Res., 22 (1.CONCLUSIONS--The SmartMist device allowed reproducible actuation of an MDI at a preprogrammed point during inspiration. The extent of aerosol deposition in the lung is affected by a change in firing point and is promoted by an inhaled flow rate of up to 90 l/min-that is, the slow and medium setting used in .